Dequalinium Chloride Effectively Disrupts Bacterial Vaginosis (BV) Gardnerella spp. Biofilms

Adherent biofilms in bacterial vaginosis.

OBJECTIVE Bacterial vaginosis is a common infectious disorder. Although known since ancient times, little progress has occurred in identifying causal factors. Our aims were to study the bacterial community structure and the spatial organization of microbiota on the epithelial surfaces of vaginal biopsy specimens. METHODS We investigated the composition and spatial organization of bacteria ass...

Bacterial Vaginosis BV-Assay White Paper

Gardnerella vaginalis does not always cause bacterial vaginosis.

TO THE EDITOR—Schwebke et al [1] present a conceptual model arguing the case for Gardnerella vaginalis as the primary etiological agent of bacterial vaginosis (BV). The model posits that G. vaginalis is a sexually acquired pathogen that elicits BV via the establishment of a bacterial biofilm on the vaginal epithelium, aided by synergistic associations with vaginal anaerobes and competitive inte...

BV and non-BV associated Gardnerella vaginalis establish similar synergistic interactions with other BV-associated microorganisms in dual-species biofilms.

Dual-species biofilm formation between Gardnerella vaginalis strains isolated from women with or without bacterial vaginosis (BV) and other 24 BV-associated microorganisms support that the key difference in virulence potential between BV-negative and BV-positive G. vaginalis strains seems not to be related with biofilm maturation.

Gardnerella vaginalis-associated bacterial vaginosis in Bulgarian women.

BACKGROUND Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of reproductive age. The purpose of this study was to determine the frequency of BV in Bulgarian pregnant and nonpregnant women from several age ranges and to compare three different laboratory methods for Gardnerella vaginalis detection in patents suffering from BV. METHODS Between September 2011 and J...